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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLXIPL All Species: 13.33
Human Site: S345 Identified Species: 22.56
UniProt: Q9NP71 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NP71 NP_116569.1 852 93073 S345 P E V P P A S S A M T H L S G
Chimpanzee Pan troglodytes XP_509441 819 90122 T305 G C E H T S R T E D P F I Q P
Rhesus Macaque Macaca mulatta XP_001115131 390 43669
Dog Lupus familis XP_546925 857 93734 S345 S E V P P A S S G V T H L S G
Cat Felis silvestris
Mouse Mus musculus Q99MZ3 864 94857 S345 P E M P S P A S S S S S S G M
Rat Rattus norvegicus Q6AXT8 471 49872
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001104311 895 97370 P345 D A P L P P S P L L Q V S G T
Frog Xenopus laevis NP_001084764 548 60887 S84 Y S F G K T S S C H L S I D A
Zebra Danio Brachydanio rerio XP_001338503 817 90800 L338 Q A S L L S S L P L S T E L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_724328 836 92381 Q340 Q E P P Q M Q Q S L P V G M G
Honey Bee Apis mellifera XP_394429 1014 115124 T463 P Y A M E I Q T V L T P V Q N
Nematode Worm Caenorhab. elegans P41846 1009 112841 S348 M R R S A S S S A S L H Q M Q
Sea Urchin Strong. purpuratus XP_788672 1338 148936 I461 A S Q G Q Q N I F S A Q P P Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LVN1 1266 139556 S559 P P L P A A A S K P S E Q L Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 41.6 42.9 87.7 N.A. 81.4 20.8 N.A. N.A. 51.4 30.9 39.4 N.A. 20 29.5 25.5 21.1
Protein Similarity: 100 55.4 43.9 91.4 N.A. 85.7 29.3 N.A. N.A. 60.7 41.6 53.5 N.A. 36.5 44.9 41.3 33.5
P-Site Identity: 100 0 0 80 N.A. 26.6 0 N.A. N.A. 13.3 13.3 6.6 N.A. 20 13.3 26.6 0
P-Site Similarity: 100 20 0 86.6 N.A. 53.3 0 N.A. N.A. 20 20 26.6 N.A. 33.3 33.3 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 20.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 34 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 8 0 15 22 15 0 15 0 8 0 0 0 8 % A
% Cys: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % D
% Glu: 0 29 8 0 8 0 0 0 8 0 0 8 8 0 0 % E
% Phe: 0 0 8 0 0 0 0 0 8 0 0 8 0 0 0 % F
% Gly: 8 0 0 15 0 0 0 0 8 0 0 0 8 15 22 % G
% His: 0 0 0 8 0 0 0 0 0 8 0 22 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 8 0 0 0 0 15 0 0 % I
% Lys: 0 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % K
% Leu: 0 0 8 15 8 0 0 8 8 29 15 0 15 15 0 % L
% Met: 8 0 8 8 0 8 0 0 0 8 0 0 0 15 8 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % N
% Pro: 29 8 15 36 22 15 0 8 8 8 15 8 8 8 15 % P
% Gln: 15 0 8 0 15 8 15 8 0 0 8 8 15 15 22 % Q
% Arg: 0 8 8 0 0 0 8 0 0 0 0 0 0 0 0 % R
% Ser: 8 15 8 8 8 22 43 43 15 22 22 15 15 15 0 % S
% Thr: 0 0 0 0 8 8 0 15 0 0 22 8 0 0 8 % T
% Val: 0 0 15 0 0 0 0 0 8 8 0 15 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _